SciShow | How Protein Shapes Help Us Make Medicine

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Episode Title: How Protein Shapes Help Us Make Medicine
Produced by: SciShow
Description: Go to http://curiositystream.com/scishow to start streaming Breakthrough. Use the promo code ‘scishow’ during the sign-up process to get your first 31 days free. Coming up with brand new drugs is all about pinpointing and exploiting a disease’s weakness. A big part of perfecting drug design will be learning to predict how proteins get their shapes because that has everything to do with how both diseases and drugs work. Hosted by: Hank Green SciShow has a spinoff podcast! It's called SciShow Tangents. Check it out at http://www.scishowtangents.org ---------- Support SciShow by becoming a patron on Patreon: https://www.patreon.com/scishow ---------- Huge thanks go to the following Patreon supporters for helping us keep SciShow free for everyone forever: Adam Brainard, Greg, Alex Hackman, Sam Lutfi, D.A. Noe, الخليفي سلطان, Piya Shedden, KatieMarie Magnone, Scott Satovsky Jr, Charles Southerland, Patrick D. Ashmore, charles george, Kevin Bealer, Chris Peters ---------- Looking for SciShow elsewhere on the internet? Facebook: http://www.facebook.com/scishow Twitter: http://www.twitter.com/scishow Tumblr: http://scishow.tumblr.com Instagram: http://instagram.com/thescishow ---------- Sources: https://www.pbs.org/newshour/health/the-real-story-behind-the-worlds-first-antibiotic https://www.cancer.gov/research/progress/discovery/gleevec https://www.nature.com/scitable/topicpage/gleevec-the-breakthrough-in-cancer-treatment-565 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055302/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238551/ https://www.ncbi.nlm.nih.gov/pubmed/17921997 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889822/ http://www.rcsb.org/pdb/results/results.do?tabtoshow=Current&qrid=69B25B99 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138819/pdf/gb-2000-1-1-comment002.pdf https://science.sciencemag.org/content/294/5540/93 https://www.biostat.wisc.edu/bmi776/lectures/Rosetta.pdf https://onlinelibrary.wiley.com/doi/full/10.1002/prot.25415 https://commons.wikimedia.org/wiki/File:TOP7-rosetta_superposition.png https://commons.wikimedia.org/wiki/File:HSQC-NMR.tiff https://commons.wikimedia.org/wiki/File:X-ray_diffraction_pattern_3clpro.jpg https://www.nature.com/articles/nrd941 https://commons.wikimedia.org/wiki/File:Spombe_Pop2p_protein_structure_rainbow.png https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1186895/ https://www.ncbi.nlm.nih.gov/books/NBK22393/ https://academic.oup.com/bioinformatics/article/23/6/717/418732 Image Sources: https://en.wikipedia.org/wiki/Amino_acid#/media/File:Amino_Acids.svg https://commons.wikimedia.org/wiki/File:Imatinib_xtal-2007-balls-and-sticks.png https://commons.wikimedia.org/wiki/File:Bruker_Avance_DPX_250_NMR_Spectrometer.jpg


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